AppleWin emulates a No-Slot clock (aka NSC).
This is a chip (a Dallas SmartWatch DS1216) that sits under one of the 28-pin ROM chips in the Apple II.
No hardware configuration is required: this chip is always present, but won't interfere with emulation when not in use.
It requires a software driver to be installed (for DOS and ProDOS). This driver then emulates the Thunderclock card.
Here's a summary of NSC/ROM chip locations and which drivers work:
Here are the drivers and ROM pages they check:
NOTE: For ProDOS, the load order of drivers is important:
Some .SYSTEM drivers will not chain-load the next driver.
NS.CLOCK.SYSTEM does, so ensure this is the first one ProDOS finds,
whereas ZIP.SYSTEM doesn't so put this at the end of the chain.