Certain scenarios (e.g. not running any Applesoft program at all since booting DOS 3.3) can make DOS 3.3 consider cc65 device input (e.g. getchar()) that reads a CR interpreting the command in the keyboard buffer. Setting the hibyte of the Applesoft currently executed line number to some value <> $FF (beside setting the input prompt to some value <> ']') makes DOS 3.3 understand that we're not in intermediate mode and that therefore I/O not preceded with ctrl-d mustn't be fiddled with (see DOS 3.3 routine at $A65E).
0f4cb443b4